My laboratory studies post-transcriptional responses in diseased and developing heart and brain using viral vectors, mouse models, human tissues, and cell culture systems. Our goal is to identify disease-related RNA-binding proteins (RBPs) and microRNAs (miRNAs) and determine their regulatory targets using computational and high-throughput biochemical means (HITS-CLIP, CLIP-seq). RBPs and miRNAs are key mediators of post-transcriptional responses, and modulation of their activities provides attractive means to manipulate gene expression for therapeutic benefit.