My research concerns the emerging field of genomic medicine. In the clinical laboratory we are interested in how new high throughput technologies can be applied in a clinically appropriate fashion. We are particularly interested in the clinical laboratory application and quality control of whole genome single nucleotide polymorphism (SNP) arrays, comparative genomic hybridization (CGH) arrays and whole genome and/or exome high throughput DNA sequencing. In the research laboratory our focus is on discovering genetic determinants of intellectual disability/cognitive developmental delay as well as recurrent genomic aberrations in both solid tumors and hematopoietic malignancies that can aid in diagnosis, prognosis, and therapeutic decision making.