The long-term research interest in Song laboratory is to elucidate the mechanisms underlying heart failure and cardiac arrhythmias, which are major public health problems world widely. The goal of his research is to identify and define the mechanisms that lead to heart failure / arrhythmias and to develop therapeutic strategies for these diseases. To achieve this goal, we apply a multidisciplinary approach including high resolution confocal imaging, patch-clamp electrophysiology, biochemistry, cellular and molecular biology as well as novel genetic mouse models developed in the lab. The Song lab also actively collaborates with other labs and investigators within the University of Iowa and outside the campus.